![]() ![]() Most cases of hypertension (90–95%) are classified as primary or essential hypertension with a multifactorial genetic–environmental etiology. Systemic arterial hypertension, commonly known as hypertension, is a multifunctional disease characterized by persistently increased blood pressure (BP) in the systemic arteries, with values over 140 mmHg for systolic BP (SBP) and over 90 mmHg for diastolic BP (DBP). To summarize, based on the available literature, only (endo)cannabinoids with a defined site of action are recommended as potential antihypertensive compounds in systemic hypertension, whereas both mono- and multitarget compounds may be effective in pulmonary hypertension. In contrast, multitarget cannabidiol and monotarget ligands effectively treated pulmonary and systemic hypertension, respectively. We found that multitarget (endo)cannabinoids failed to modify higher BP in systemic hypertension since they induced responses leading to decreased and increased BP. We considered vasodilator or blood pressure (BP) responses and cardioprotective, anti-oxidative, and the anti-inflammatory effects of particular compounds and their influence on the endocannabinoid system. ![]() Unfortunately, our review, in which we summarized all publications found in the PubMed database regarding chronic administration of (endo)cannabinoids in experimental models of systemic and pulmonary hypertension, does not confirm any encouraging suggestions, being based mainly on in vitro and acute in vivo experiments. ![]() (Endo)cannabinoids, known for their strong vasodilatory properties, have been proposed as possible drugs for different types of hypertension. Searching for new therapeutic strategies is still an important task. The first one is a civilizational condition, and the second one is characterized by a very high mortality rate. Systemic and pulmonary hypertension are multifactorial, high-pressure diseases. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |